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January 7, 2004Current Medical Research and Opinion

Advances in the treatment of diabetic renal disease: focus on losartan

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Why the study?

Does losartan reduce the progression to ESRD and cardiovascular events in patients with type 2 diabetes mellitus and nephropathy?

Population

Patients with type 2 diabetes mellitus (T2DM) and hypertension or nephropathy

Design

Review

Authors

BRBrian Rayner

Discussion

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Overview

Supports losartan consideration in T2DM nephropathy; leaves open need for updated RCTs versus contemporary therapies.

Structured PICO

Does losartan reduce the progression to ESRD and cardiovascular events in patients with type 2 diabetes mellitus and nephropathy?

P
Population
Patients with type 2 diabetes mellitus (T2DM) and hypertension or nephropathy
I
Intervention
Losartan
O
Outcome
Progression to end stage renal disease (ESRD) and doubling of serum creatininehard clinical

This review highlights that losartan is an effective treatment for reducing the progression of diabetic nephropathy and the risk of ESRD and cardiovascular events in patients with T2DM.

Cite This Study

Brian Rayner (2004) studied this question.

synapsesocial.com/papers/6a84f4ad59798a3cd2e588ddhttps://doi.org/10.1185/030079903125003107
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renal effects of losartan and amlodipine in hypertensive patients with non-diabetic nephropathy1998 · 61 citations
  2. 2Inhibition of Platelet Activation in Stroke-Prone Spontaneously Hypertensive Rats: Comparison of Losartan, Candesartan, and Valsartan2001 · 28 citations
  3. 3Salt intake and non-ACE pathways for intrarenal angiotensin II generation in man2001 · 19 citations
  4. 4ACE Inhibitor Effects on Platelet Function in Stages I-II Hypertension1997 · 30 citations
  5. 5End stage renal disease and dialysis report1996 · 100 citations