Why the study?
Does apocynin improve post-MI left ventricular failure in a mouse model of type 2 diabetes?
Population
Male C57BL/6J mice fed on either high-fat diet or normal diet for 8 weeks, with myocardial infarction…
Comparison
Apocynin 10 mmol/l vs Vehicle
Design
Preclinical
Follow-up
4 weeks post-MI
Authors
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Apocynin attenuates post-MI LV failure exacerbation in diabetic mice; hypothesis-generating for NAD(P)H oxidase inhibition before human translation.
Does apocynin improve post-MI left ventricular failure in a mouse model of type 2 diabetes?
Inhibition of NAD(P)H oxidase with apocynin attenuates the exacerbation of post-MI left ventricular failure in a mouse model of type 2 diabetes.
Matsushima et al. (2009) studied this question.
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