Key result
In mice with postinfarct heart failure, apocynin treatment ameliorated oxidative stress and improved insulin resistance, inhibiting the 61% and 23% decreases in Akt phosphorylation and GLUT4.
Why the study?
Does apocynin improve insulin resistance and insulin signaling in mice with postinfarct heart failure?
Population
Mice with postinfarct heart failure (after myocardial infarction)
Comparison
Apocynin (an inhibitor of NADH oxidase… vs Sham operated mice, sham treated with apocynin…
Design
Preclinical
Follow-up
4 weeks
Authors
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Apocynin may improve insulin resistance in experimental postinfarct HF; leaves open translation of NAD(P)H oxidase inhibition to human patients.
Does apocynin improve insulin resistance and insulin signaling in mice with postinfarct heart failure?
In a mouse model of postinfarct heart failure, inhibiting NAD(P)H oxidase with apocynin reduces oxidative stress and restores insulin signaling in skeletal muscle, thereby improving insulin resistance.
Ohta et al. (2011) studied postinfarct heart failure. apocynin vs. sham, MI without apocynin was evaluated on insulin resistance and insulin signaling. In mice with postinfarct heart failure, apocynin treatment ameliorated oxidative stress and improved insulin resistance, inhibiting the 61% and 23% decreases in Akt phosphorylation and GLUT4.
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