June 28, 2011HypertensionOpen Access

Aerobic Exercise Training–Induced Left Ventricular Hypertrophy Involves Regulatory MicroRNAs, Decreased Angiotensin-Converting Enzyme-Angiotensin II, and Synergistic Regulation of Angiotensin-Converting Enzyme 2-Angiotensin (1-7)

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Population

Rats assigned to 3 groups (sedentary, moderate-volume swimming, high-volume swimming)

Comparison

Aerobic exercise training with moderate-volume… vs Sedentary rats

Design

Preclinical

Authors

TFTiago Lazzaretti FernandesOrthopaedic Center NHNara Yumi HashimotoHashimoto Municipal Hospital FMFlávio de Castro MagalhãesNew Mexico Department of Health

Discussion

Member takes

Implication

Hypothesis-generating in rats; human studies needed to assess translational relevance to exercise-induced cardiac remodeling.

Structured PICO

Population

Rats assigned to 3 groups (sedentary, moderate-volume swimming, high-volume swimming)

Intervention

Aerobic exercise training (swimming) with moderate-volume (T1) or high-volume (T2) protocols

Comparator

Sedentary rats

Outcome

Levels of cardiac renin-angiotensin system components (Ang I, Ang II, ACE, ACE2, Ang (1-7), AT1R, AT2R) and regulatory microRNAs (miR-27a, miR-27b, miR-143)surrogate

Aerobic exercise induces physiological left ventricular hypertrophy in rats by altering specific microRNAs that shift the cardiac renin-angiotensin system balance toward the ACE2-Ang (1-7) axis.

Cite This Study

Fernandes et al. (2011) studied this question.

synapsesocial.com/papers/6a84f7cc39166d68e0e58abf https://doi.org/10.1161/hypertensionaha.110.168252

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Aerobic Exercise Training–Induced Left Ventricular Hypertrophy Involves Regulatory MicroRNAs, Decreased Angiotensin-Converting Enzyme-Angiotensin II, and Synergistic Regulation of Angiotensin-Converting Enzyme 2-Angiotensin (1-7)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Aerobic Exercise Training–Induced Left Ventricular Hypertrophy Involves Regulatory MicroRNAs, Decreased Angiotensin-Converting Enzyme-Angiotensin II, and Synergistic Regulation of Angiotensin-Converting Enzyme 2-Angiotensin (1-7)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider