Why the study?
Does protocatechuic acid improve cardiac function and metabolic parameters in a rat model of type 1 diabetes?
Population
Male Sprague-Dawley rats with type 1 diabetes induced by a single i.p. injection of 50 mg/kg streptozotocin
Comparison
Protocatechuic acid orally at 50 mg/kg/day or… vs Oral administration of vehicle for 12 weeks
Design
Preclinical
Follow-up
12 weeks
Authors
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Hypothesis-generating for protocatechuic acid in diabetic cardiomyopathy; human trials needed before any clinical consideration.
Does protocatechuic acid improve cardiac function and metabolic parameters in a rat model of type 1 diabetes?
Protocatechuic acid exerts cardioprotective effects by improving cardiac function, autonomic balance, and mitochondrial function in a rat model of type 1 diabetes.
Semaming et al. (2014) studied this question.
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