What question did this study set out to answer?

To assess reflex inhibition of renal sympathetic nerve outflow triggered by cardiac receptor activation during volume loading in normotensive versus spontaneously hypertensive rats.

May 1, 1979Acta Physiologica Scandinavica

Inhibition of renal sympathetic nerve traffic from cardiac receptors in normotensive and spontaneously hypertensive rats

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Why the study?

Does the threshold for reflex inhibition of renal sympathetic outflow during volume load differ between normotensive and spontaneously hypertensive rats?

Population

12 rats, anesthetized with chloralose and urethane, with denervated arterial baroreceptors

Comparison

Volume load with horse plasma vs Normotensive rats vs. spontaneously hypertensive…

Design

Preclinical

Authors

SRSven‐Erik RickstenUniversity of Gothenburg ENEddy NoressonUniversity of Gothenburg PTPeter ThorénCross-Cutting Cardiology

Discussion

Member takes

Implication

Higher threshold in hypertensive models suggests reflex resetting; hypothesis-generating for cardiac-renal interactions in human hypertension.

Key Points

To assess reflex inhibition of renal sympathetic nerve outflow triggered by cardiac receptor activation during volume loading in normotensive versus spontaneously hypertensive rats.
Studied 6 normotensive control rats (NCR) and 6 spontaneously hypertensive rats (SHR) anesthetized with chloralose and urethane.
Performed arterial baroreceptor denervation and induced volume loading using horse plasma while monitoring vagally mediated renal nerve inhibition and left atrial pressure.
Renal sympathetic nerve inhibition was primarily mediated via vagal afferents responding to mechanoreceptors in the left side of the heart.
The threshold mean left atrial pressure required to elicit renal nerve inhibition was 5.4 mmHg in NCR versus 9.2 mmHg in SHR.
The increased pressure threshold in SHR indicates a reflex arc resetting, likely caused by decreased left atrial wall distensibility from chronic pressure elevation.

Structured PICO

Does the threshold for reflex inhibition of renal sympathetic outflow during volume load differ between normotensive and spontaneously hypertensive rats?

Population

12 rats (6 normotensive rats [NCR] and 6 spontaneously hypertensive rats [SHR]), anesthetized with chloralose and urethane, with denervated arterial baroreceptors

Intervention

Volume load with horse plasma

Comparator

Normotensive rats vs. spontaneously hypertensive rats

Outcome

Threshold in mean left atrial pressure for renal nervous inhibitionsurrogate

Spontaneously hypertensive rats exhibit a resetting of the reflex arc for renal nervous inhibition, requiring higher left atrial pressures, likely due to decreased left atrial distensibility.

Cite This Study

Ricksten et al. (1979) studied this question.

synapsesocial.com/papers/6a84f80439166d68e0e58af0 https://doi.org/10.1111/j.1748-1716.1979.tb06364.x

Topics

Hypertension management

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Implication

Higher threshold in hypertensive models suggests reflex resetting; hypothesis-generating for cardiac-renal interactions in human hypertension.

Inhibition of renal sympathetic nerve traffic from cardiac receptors in normotensive and spontaneously hypertensive rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Inhibition of renal sympathetic nerve traffic from cardiac receptors in normotensive and spontaneously hypertensive rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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