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Supports hERG screening in drug safety; leaves open its modulation as therapeutic target.
Potassium channels encoded by the human ether-a-go-go–related gene (hERG) are of crucial importance for the repolarization of the cardiac action potential, as they constitute the main component of the cardiac delayed rectifier current, IKr ([Sanguinetti et al., 1995][1]). The primary sequence of
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León D Islas (2013) studied this question.
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