Why the study?
Does a combined schedule of OPV and IPV improve serum antibody response against poliovirus in infants compared to OPV or IPV alone?
Population
1685 enrolled infants in The Gambia, Oman, and Thailand
Comparison
Combined schedule: oral poliovirus vaccine at… vs OPV at birth and at 6, 10, and 14 weeks of age…
Design
RCT, randomized
Follow-up
24 weeks
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Supports combined OPV-IPV schedules for routine infant immunization; extends RCT evidence for sequential polio vaccination strategies.
Does a combined schedule of OPV and IPV improve serum antibody response against poliovirus in infants compared to OPV or IPV alone?
A combined schedule of OPV and IPV provides the highest levels of serum antibody response against poliovirus while maintaining mucosal immunity equivalent to OPV alone.
A 1997 study studied this question.
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