Population
Enterovirus 71 (EV71) RNA-dependent RNA polymerase (3D(pol)) and VPg protein complex
Comparison
Mutations of amino acids of 3D involved in VPg… vs Wild-type EV71 3D(pol)
Design
Preclinical
Authors
Loading...
These residues may represent EV71 antiviral targets; leaves open clinical translation from animal models.
The crystal structure of EV71 3D(pol) complexed with VPg reveals a trans mechanism for VPg uridylylation, which is essential for viral replication.
Chen et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: