The Pathogenesis of Congenital Cardiovascular Anomalies

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Population

Offspring of mothers suffering from rubella in the first trimester

Design

Review

Authors

Discussion

Underscores preconception rubella vaccination; confirms classic teratogenicity but leaves open current risk estimates in vaccinated populations.

Population

Offspring of mothers suffering from rubella in the first trimester

Intervention

Maternal rubella infection in the first trimester

Outcome

Congenital cardiovascular and other anomalies

Maternal rubella infection during the first trimester is a recognized environmental cause of congenital cardiovascular anomalies.

Benjamin T. Jackson (1968) studied this question.

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Underscores preconception rubella vaccination; confirms classic teratogenicity but leaves open current risk estimates in vaccinated populations.