A new improved synthesis of 1,4-dichloro- and 1,4-dibroniophthalazine has been effected by reaction of 1,4-dioxophthalazine with PX 5 (X = Cl, Br) in a sealed reaction flask. Halogenation of the dioxophthalazine has also been accomplished at atmospheric pressure in a halogenated solvent. The synthesis of 1-bromophthalazine is reported.
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Hirsch et al. (1965) studied this question.
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