What question did this study set out to answer?

To evaluate ventilatory efficiency for carbon dioxide during exercise and determine its contribution to exercise intolerance in patients with pulmonary hypertension.

July 1, 1998Clinical Physiology

Ventilatory inefficiency for carbon dioxide during exercise in patients with pulmonary hypertension

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To evaluate ventilatory efficiency for carbon dioxide during exercise and determine its contribution to exercise intolerance in patients with pulmonary hypertension.
Assessed exercise performance and ventilatory parameters in 10 patients with pulmonary hypertension, 37 patients with normal pulmonary artery pressure after shunt repair, and age-matched healthy controls.
Measured aerobic performance by ventilatory threshold and quantified carbon dioxide ventilatory efficiency using the slope of ventilation over carbon dioxide output below that threshold.
Patients with pulmonary hypertension displayed a significantly steeper ventilation versus carbon dioxide output slope (48 ± 12) compared to patients with normal pulmonary artery pressure (31.3 ± 7.0, P < 0.05).
Pulmonary artery pressure correlated significantly with the ventilation over carbon dioxide slope (r = 0.92, P < 0.05) and the maximal exercise physiological dead space-tidal volume ratio (r = 0.55, P < 0.05).
Exercise capacity was severely impaired in pulmonary hypertension patients, whereas performance in patients with normal pulmonary artery pressure was only slightly below normal limits.

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Implication

Comparative study demonstrates elevated ventilatory response to carbon dioxide in pulmonary hypertension patients, indicating that ventilatory inefficiency limits exercise tolerance.

Cite This Study

Reybrouck et al. (1998) studied this question.

synapsesocial.com/papers/6a851e33385dd211e7c2a2bf https://doi.org/10.1046/j.1365-2281.1998.00109.x

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Implication

Comparative study demonstrates elevated ventilatory response to carbon dioxide in pulmonary hypertension patients, indicating that ventilatory inefficiency limits exercise tolerance.

Ventilatory inefficiency for carbon dioxide during exercise in patients with pulmonary hypertension

Key Points

Discussion

Implication

Cite This Study

Ventilatory inefficiency for carbon dioxide during exercise in patients with pulmonary hypertension

Key Points

Discussion

Implication

Cite This Study

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