Key result
Sildenafil treatment for 12 weeks reduced the Ve/Vco(2) slope by 8% (P=0.02) compared to placebo in patients with systolic heart failure.
Why the study?
Does sildenafil improve ventilatory efficiency in patients with systolic heart failure?
RCT
Does sildenafil improve ventilatory efficiency in patients with systolic heart failure?
p-value: p=0.02
In patients with systolic heart failure, ventilatory efficiency is closely linked to right ventricular function and pulmonary vascular tone, and can be improved with sildenafil.
No takes yet. Share an insight, caveat, or question.
May support sildenafil for ventilatory efficiency in systolic HF; hypothesis-generating and requires randomized confirmation before practice change.
Lewis et al. (2008) conducted an RCT in Systolic heart failure. Sildenafil vs. Placebo was evaluated on Change in Ve/Vco(2) slope (p=0.02). Sildenafil treatment for 12 weeks reduced the Ve/Vco(2) slope by 8% (P=0.02) compared to placebo in patients with systolic heart failure.
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