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September 10, 1986Diabetic Medicine

The Relationship Between Autonomic Neuropathy and Urinary Sodium and Albumin Excretion in Insulin‐Treated Diabetics

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Why the study?

Does autonomic neuropathy affect urinary sodium and albumin excretion in insulin-treated diabetics?

Population

40 insulin-treated diabetics, matched for age, sex, duration of diabetes, diabetic control, and systolic…

Comparison

Presence of established autonomic neuropathy vs Absence of autonomic neuropathy

Design

Case-control

Authors

PWPeter WinocourEast and North Hertfordshire NHS TrustHDH. DharUniversity of OxfordDADavid C. AndersonUniversity of Calgary

Discussion

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Implication

Autonomic neuropathy may link to nocturnal albuminuria and natriuresis in insulin-treated diabetes; hypothesis-generating, needs prospective confirmation.

Structured PICO

Does autonomic neuropathy affect urinary sodium and albumin excretion in insulin-treated diabetics?

P
Population
40 insulin-treated diabetics (20 with established autonomic neuropathy, 20 without), matched for age, sex, duration of diabetes, diabetic control, and systolic blood pressure, free of proteinuria on albustix testing and with normal serum urea and creatinine.
I
Intervention
Presence of established autonomic neuropathy
C
Comparator
Absence of autonomic neuropathy
O
Outcome
Albumin excretion rate (AER) and sodium excretion rate (NaER) in timed daytime (erect) and night-time (supine) urine collectionssurrogate

Autonomic neuropathy in insulin-treated diabetics is associated with deranged nocturnal renal hemodynamics, evidenced by increased nocturnal albumin and sodium excretion.

Cite This Study

Winocour et al. (1986) studied this question.

synapsesocial.com/papers/6a851ecc76469a949f43cfd5https://doi.org/10.1111/j.1464-5491.1986.tb00786.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early detection of patients at risk of developing diabetic nephropathy. A longitudinal study of urinary albumin excretion1982 · 574 citations
  2. 2Plasma Renin Activity in Diabetic Autonomic Neuropathy1976 · 37 citations
  3. 3Comparison of the Renin Response to Dopamine and Noradrenaline in Normal Subjects and Patients with Autonomic Insufficiency1974 · 33 citations
  4. 4Effects of Posture on Renal Excretion of Sodium and Chloride in Orthostatic Hypotension1953 · 35 citations
  5. 5Diagnosis and management of diabetic autonomic neuropathy.1982 · 1,236 citations