Why the study?
Does sulphated polysaccharide (PZ 68) prevent deep vein thrombosis and pulmonary embolism compared to dextran 70 in patients with fracture of the femoral neck?
Does sulphated polysaccharide (PZ 68) prevent deep vein thrombosis and pulmonary embolism compared to dextran 70 in patients with fracture of the femoral neck?
PZ 68 and dextran 70 showed no significant difference in preventing thromboembolic events in femoral neck fracture patients, though PZ 68 was associated with major hemorrhage.
Answers are grounded in this paper and cite their sources.
No thromboembolic benefit of PZ 68 over dextran 70 after femoral neck fracture; challenges its adoption given major hemorrhage risk.
A prospective and randomized study of 100 patients with fracture of the femoral neck was carried out. The aim was to compare the thromboembolic prophylactic effect of dextran 70 and a sulphated polysaccharide, PZ 68. Deep vein thrombosis was diagnosed using the 125I-fibrinogen test and phlebography, and pulmonary embolism with a perfusion and ventilation scan. The number of thromboses and emboli did not differ significantly between the two groups. However, there was a general tendency for predominance of thrombosis on the operated side. Six patients were excluded in the PZ 68 group because of major haemorrhage.
No takes yet. Share an insight, caveat, or question.
Fredin et al. (1982) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: