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September 1, 1989Journal of General Virology

A Cassette Vector for the Construction of Antigen Chimaeras of Poliovirus

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Population

Sabin 1 poliovirus vaccine strain, P1/LSc 2ab

Design

Preclinical

Authors

KBKaren L. BurkeThe Pirbright InstituteDEDavid J. EvansUniversity of OxfordOJOwen JenkinsHealth and Safety Authority

Discussion

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Implication

Facilitates rapid Sabin 1 variant engineering; animal data leave open human vaccine relevance.

Structured PICO

P
Population
Sabin 1 poliovirus vaccine strain, P1/LSc 2ab
I
Intervention
Construction of a cassette vector with unique restriction endonuclease sites flanking antigenic site 1
O
Outcome
Ability to replace the region by oligonucleotides encoding foreign amino acid sequences

A cassette vector was successfully constructed to allow rapid modification of the neutralizing antigenic site 1 of the Sabin 1 poliovirus vaccine strain.

Cite This Study

Burke et al. (1989) studied this question.

synapsesocial.com/papers/6a8525a676469a949f43d281https://doi.org/10.1099/0022-1317-70-9-2475
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Construction of a "mutagenesis cartridge" for poliovirus genome-linked viral protein: isolation and characterization of viable and nonviable mutants.1988 · 44 citations
  2. 2Three-dimensional structure of poliovirus serotype 1 neutralizing determinants1988 · 222 citations
  3. 3Construction of poliovirus intertypic recombinants by use of cDNA1986 · 34 citations
  4. 4Antigenic Structure of Polioviruses of Serotypes 1, 2 and 31986 · 309 citations
  5. 5Synthesis of infectious poliovirus RNA by purified T7 RNA polymerase.1986 · 342 citations