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March 1, 1986Journal of VirologyOpen Access

Construction of poliovirus intertypic recombinants by use of cDNA

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Population

Poliovirus type 1 and type 3 cDNA constructs

Design

Preclinical

Authors

GSGlyn StanwayUniversity of EssexPHP. J. HughesUniversity of EssexGWGareth D. WestropUniversity of Strathclyde

Discussion

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Implication

Some cDNA constructs yield infectious poliovirus recombinants while others fail; leaves open capsid determinants of viability for further mapping.

Structured PICO

P
Population
Poliovirus type 1 and type 3 cDNA constructs
I
Intervention
Use of infectious cDNA for the production of intertypic recombinants
O
Outcome
Production of viable recombinant viruses

The use of infectious cDNA can produce poliovirus recombinants, though not all constructs yield viable viruses.

Cite This Study

Stanway et al. (1986) studied this question.

synapsesocial.com/papers/6a716670f44fa9f079df3285https://doi.org/10.1128/jvi.57.3.1187-1190.1986
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of Strains of Type 3 Poliovirus by Oligonucleotide Mapping1982 · 48 citations
  2. 2Regulation of Simian Virus 40 Transcription: Sensitive Analysis of the RNA Species Present Early in Infections by Virus or Viral DNA1979 · 621 citations
  3. 3In vitro phenotypic markers of a poliovirus recombinant constructed from infectious cDNA clones of the neurovirulent Mahoney strain and the attenuated Sabin 1 strain1985 · 64 citations
  4. 4Reversion to neurovirulence of the live-attenuated Sabin type 3 oral pollovirus vaccine1984 · 149 citations
  5. 5Production of infectious poliovirus from cloned cDNA is dramatically increased by SV40 transcription and replication signals1984 · 122 citations