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September 28, 1981FEBS Letters

The fate of VPg during in vitro translation of poliovirus RNA

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Population

Poliovirus RNA (vRNA and mRNA) in vitro translation models

Design

Preclinical

Authors

ADAndrew J. DornerTakeda (United States)PRPaul G. RothbergUniversity of Rochester Medical CenterEWEckard WimmerCalifornia Institute of Technology

Discussion

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Overview

May inform VPg-targeted antivirals; leaves open in vivo relevance and clinical translation.

Structured PICO

P
Population
Poliovirus RNA (vRNA and mRNA) in vitro translation models
I
Intervention
In vitro translation conditions (ribosome binding conditions, protein synthesis inhibitors)
O
Outcome
Unlinking activity of VPg and cellular proteinase activity degrading free VPgsurrogate

The study characterizes the unlinking of VPg from poliovirus RNA and its subsequent degradation by cellular proteinases during in vitro translation.

Cite This Study

Dorner et al. (1981) studied this question.

synapsesocial.com/papers/6a8525cc38b24859dfd6a048https://doi.org/10.1016/0014-5793(81)81164-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The 5'-terminal structures of poliovirion RNA and poliovirus mRNA differ only in the genome-linked protein VPg.1977 · 182 citations
  2. 2O4-(5'-uridylyl)tyrosine is the bond between the genome-linked protein and the RNA of poliovirus.1978 · 250 citations
  3. 35'-terminal structure of poliovirus polyribosomal RNA is pUp.1976 · 243 citations
  4. 4Covalent linkage of a protein to a defined nucleotide sequence at the 5'-terminus of virion and replicative intermediate RNAs of poliovirus.1977 · 348 citations
  5. 5Structural difference between the 5' termini of viral and cellular mRNA in poliovirus-infected cells: possible basis for the inhibition of host protein synthesis1976 · 120 citations