Why the study?
Does propranolol therapy improve blood pressure control and plasma renin activity in hypertensive dialysis patients?
Does propranolol therapy improve blood pressure control and plasma renin activity in hypertensive dialysis patients?
Propranolol is effective for managing hypertension in dialysis patients, but measuring plasma levels is recommended to assess compliance in refractory cases.
Noncompliance linked to hyperreninemia and poor BP control; leaves open whether renin monitoring improves propranolol adherence in dialysis patients.
The effect of propranolol therapy on plasma renin activity and blood pressure control was evaluated in 35 uremic patients receiving intermittent center-based outpatient hemodialysis. Patients were determined to be either compliant or noncompliant with therapy based on the steady-state predialysis plasma propranolol concentration. Noncompliance occurred with remarkable frequency and was associated with persistent hyperreninemia and poorly controlled hypertension. Blood pressure control was significantly better in compliant patients, in whom plasma renin activity was generally, but not universally, suppressed. Propranolol can be effectively used in the management of hypertensive dialysis patients, but steady-state plasma propranolol levels should be measured to assess compliance in patients apparently refractory to treatment.
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Briggs et al. (1975) studied this question.
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