Why the study?
Does vasopressin infusion alter the diuretic response to left atrial distension compared to saline?
Population
Experimental model undergoing left atrial distension
Comparison
Vasopressin infusion at four different dose rates vs Saline infusion
Design
Preclinical
Authors
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May support reduced vasopressin mediating left atrial distension diuresis in animals; leaves open any clinical translation or human relevance.
Does vasopressin infusion alter the diuretic response to left atrial distension compared to saline?
The diuretic response to left atrial distension may partially depend on a decrease in the concentration of circulating antidiuretic hormone.
Ledsome et al. (1972) studied this question.
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