Why the study?
Does left atrial distension alter urinary excretion in anaesthetized dogs?
Population
Anaesthetized dogs
Comparison
Distension of the left atrium for a 90 min period vs Control values (baseline/post-release)
Design
Preclinical
Follow-up
90 minutes
Authors
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Animal data on left atrial distension warrant no change in clinical volume management; leaves open mechanisms and human translation of renal responses.
Does left atrial distension alter urinary excretion in anaesthetized dogs?
Left atrial distension induces a transient diuretic response in dogs, likely mediated by both prolonged neurohypophyseal ADH suppression and short-lived hemodynamic mechanisms.
Lawrence et al. (1973) studied this question.
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