Population
Dogs (donor and recipient dogs for isolated kidney perfusion model)
Design
Preclinical
Authors
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Supports humoral natriuresis via blood-borne factor in animals; leaves open translation to human volume regulation or therapy.
Left atrial distension induces diuresis and natriuresis in an isolated perfused kidney, supporting the existence of a blood-borne diuretic agent released in response to atrial stretch.
Carswell et al. (1970) studied this question.
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