Key result
Both synthetic atriopeptin III infusion and left atrial distension caused significant increases in urine flow and electrolyte excretion, and a significant decrease in renal blood flow in conscious dogs.
Why the study?
Does intravenous atriopeptin III infusion mimic the renal and hemodynamic effects of left atrial distension in conscious dogs?
Does intravenous atriopeptin III infusion mimic the renal and hemodynamic effects of left atrial distension in conscious dogs?
This preclinical study suggests that the renal response to left atrial distension is largely mediated by the release of natriuretic peptides from the atria.
Answers are grounded in this paper and cite their sources.
Supports natriuretic peptide mediation of atrial distension effects in dogs; hypothesis-generating and should not change clinical practice.
We infused synthetic atriopeptin III intravenously into 10 conscious dogs while monitoring renal function and systemic hemodynamics. The results obtained from these infusion experiments were compared with results from other experiments in which left atrial distension was performed in the same dogs. Both atriopeptin infusion and left atrial distension caused significant increases in urine flow, sodium excretion, potassium excretion, and free water reabsorption and a significant decrease in renal blood flow. On the other hand, the pattern of systemic hemodynamic responses to atriopeptin infusion were quite different from the hemodynamic responses elicited by left atrial distension. However, there was a striking concordance between the renal effects of atriopeptin and those of left atrial distension. We therefore hypothesize that the renal response to left atrial distension in the conscious dog is mediated largely by the release of natriuretic peptides from the atria.
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Goetz et al. (1986) studied this question. Synthetic atriopeptin III infusion vs. Left atrial distension was evaluated on Renal function and systemic hemodynamics. Both synthetic atriopeptin III infusion and left atrial distension caused significant increases in urine flow and electrolyte excretion, and a significant decrease in renal blood flow in conscious dogs.
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