April 1, 1985AJP Heart and Circulatory Physiology
Atriopeptins: renal-specific vasodilators in conscious dogs
Key result
Atriopeptins increase renal blood flow up to ~27% via selective renal vasodilation.
Why the study?
The renal and systemic hemodynamic effects of atriopeptins I, II, and III in conscious dogs were not fully characterized.
PICO
P
Population
Conscious dogs instrumented to study the effects of atriopeptins on renal, iliac, mesenteric, and coronary blood flow.
I
Intervention / Comparator
Atriopeptins II and III vs Atriopeptin I and Nitroglycerin (5 micrograms/kg)
O
Primary Outcome
Renal blood flow
Authors
Discussion
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Implication
May guide natriuretic peptide development for renal perfusion; extends canine physiology but leaves human translation open.
Cite This Study
Hintze et al. (1985) studied this question. Atriopeptins II and III vs. Atriopeptin I and Nitroglycerin was evaluated on Renal blood flow. In conscious dogs, intravenous atriopeptins II and III (5 µg/kg) increased renal blood flow by 27% and 18%, respectively, acting as potent selective renal vasodilators without systemic effects.