Why the study?
Recent studies have reported the role of M3R encoded by the CHRM3 gene in cardiac function and BP regulation, but its association with salt sensitivity and hypertension risk in Chinese adults was unclear.
Are CHRM3 genetic variants associated with salt sensitivity, longitudinal blood pressure changes, and the incidence of hypertension in Chinese adults?
Are CHRM3 genetic variants associated with salt sensitivity, longitudinal blood pressure changes, and the incidence of hypertension in Chinese adults?
Genetic variations in the CHRM3 gene are associated with salt sensitivity, longitudinal blood pressure progression, and an increased risk of developing hypertension in Chinese adults.
CHRM3 variants may link to salt sensitivity and BP changes; hypothesis-generating, requires replication before any clinical role.
Recent studies have reported the role of the M3 muscarinic acetylcholine receptor (M3R), a member of the G-protein coupled receptor superfamily, encoded by the CHRM3 gene, in cardiac function and the regulation of blood pressure (BP). The aim of this study was to investigate the associations of CHRM3 genetic variants with salt sensitivity, longitudinal BP changes, and the development of hypertension in a Chinese population. We conducted a chronic dietary salt intervention experiment in a previously established Chinese cohort to analyze salt sensitivity of BP. Additionally, a 14-year follow-up was conducted on all participants in the cohort to evaluate the associations of CHRM3 polymorphisms with longitudinal BP changes, as well as the incidence of hypertension. The single nucleotide polymorphism (SNP) rs10802811 within the CHRM3 gene displayed significant associations with low salt-induced changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), while rs373288072, rs114677844, and rs663148 exhibited significant associations with SBP and MAP responses to a high-salt diet. Furthermore, the SNP rs58359377 was associated with changes in SBP and pulse pressure (PP) over the course of 14 years. Additionally, the 14-year follow-up revealed a significant association between the rs619288 polymorphism and an increased risk of hypertension (OR = 1.74, 95% CI: 1.06-2.87, p = .029). This study provides evidence that CHRM3 may have a role in salt sensitivity, BP progression, and the development of hypertension.
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Zhang et al. (2023) studied this question.
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