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September 1, 2021Open Access

Prognostic significance of carbohydrate antigen 125 in acute heart failure: a prospective comparative study with N-terminal pro-B-type natriuretic peptide

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Why the study?

Elevated CA125 and NTproBNP correlate with adverse events in AHF, but their comparative and incremental prognostic usefulness needed quantification.

Does elevated CA125 add prognostic value to NTproBNP for predicting death or heart failure readmission in patients with acute heart failure?

Population

352 patients admitted for AHF

Comparison

Dichotomized CA125 and NTproBNP levels based on optimal cut-offs

Design

Prospective comparative study

Follow-up

6-month

Authors

ZJZhang JiWLWenhua LiGCGaojun Cai

Discussion

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Member takes

Overview

CA125 may enhance acute HF risk stratification beyond NTproBNP; leaves open prospective validation and therapeutic impact.

Structured PICO

Does elevated CA125 add prognostic value to NTproBNP for predicting death or heart failure readmission in patients with acute heart failure?

P
Population
352 patients admitted for acute heart failure (AHF)
I
Intervention
Elevated carbohydrate antigen 125 (CA125 ≥ 39.7 U/ml) and N-terminal pro-B-type natriuretic peptide (NTproBNP ≥ 3900 pg/ml)
C
Comparator
CA125 < 39.7 U/ml and NTproBNP < 3900 pg/ml
O
Outcome
6-month combined endpoint of death or AHF rehospitalizationcomposite

CA125 provides incremental prognostic value over NTproBNP for predicting 6-month death or rehospitalization in patients with acute heart failure.

Cite This Study

Ji et al. (2021) studied this question.

synapsesocial.com/papers/6a85307f4b2893ddcbc6b22bhttps://doi.org/10.21203/rs.3.rs-864855/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevated CA125 values predict adverse outcomes in acute heart failure.2024 · 2 citations
  2. 2Prognostic value of carbohydrate antigen 125 combined with N-terminal pro B-type natriuretic peptide in patients with acute heart failure2020 · 6 citations
  3. 3Prognostic value of carbohydrate antigen 125 combined with N-terminal pro B-type natriuretic peptide in patients with acute heart failure: a prospective cohort study in Vietnam2025 · 1 citations
  4. 4Prognostic value of increased carbohydrate antigen in patients with heart failure2014 · 10 citations
  5. 5Improvement in risk stratification with the combination of the tumour marker antigen carbohydrate 125 and brain natriuretic peptide in patients with acute heart failure2010 · 126 citations