Key result
Elevated CA125 and NT-proBNP levels were associated with a significantly higher risk of mortality in stable heart failure compared to non-elevated levels (HR 8.95; 95% CI 3.11-25.73; P<0.001).
Why the study?
Does elevated CA125 add prognostic value to NT-proBNP in predicting outcomes in patients with stable heart failure?
Cohort (n=156)
Does elevated CA125 add prognostic value to NT-proBNP in predicting outcomes in patients with stable heart failure?
Hazard Ratio: 8.95 (95% CI 3.11–25.73)
p-value: p=<0.001
Elevated CA125 (>60 KU/L) identifies stable heart failure patients with poor survival and adds incremental prognostic value to NT-proBNP.
No takes yet. Share an insight, caveat, or question.
May support combined CA125/NT-proBNP risk stratification in stable HF; leaves open need for prospective validation before practice change.
A. Méndez (2014) conducted a cohort in stable heart failure (n=156). Elevated CA125 and NT-proBNP vs. Not elevated was evaluated on Mortality (HR 8.95, 95% CI 3.11-25.73, p=<0.001). Elevated CA125 and NT-proBNP levels were associated with a significantly higher risk of mortality in stable heart failure compared to non-elevated levels (HR 8.95; 95% CI 3.11-25.73; P<0.001).
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