Key result
Elevated CA-125 is linked to ~23% higher mortality in acute decompensated heart failure.
Why the study?
The long-term prognostic value of CA-125 in combination with NT-proBNP in patients with acute decompensated heart failure was not established.
Observational (n=413)
No
Hazard Ratio: 1.23 (95% CI 1.02–1.48)
p-value: p=0.030
May aid risk stratification in acute decompensated HF beyond NT-proBNP; hypothesis-generating and requires prospective validation.
BACKGROUND/AIMS: Carbohydrate antigen 125 (CA-125) is an emerging prognostic biomarker for heart failure. We aimed to test the long-term prognostic value of CA-125 in combination with N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute decompensated heart failure (ADHF). METHODS: This observational study included a total of 413 patients (64.1 ± 15.6 yearold, 214 men) with ADHF. All-cause mortality during the 2-year follow-up was investigated for the prognosis. RESULTS: During the follow-up (mean follow-up, 591 ± 233 days), 109 deaths (26.0%) were recorded. In the multivariable analysis model, CA-125 was an independent factor associated with all-cause mortality (log CA-125: hazard ratio, 1.23; 95% confidence interval, 1.02 to 1.48; p = 0.030) together with age, sex, New York Heart Association class, β-blocker, and NT-proBNP. The Kaplan-Meier survival analysis demonstrated that the group with both low marker levels showed the best 2-year survival (87.9%) followed by the group with low NT-proBNP and high CA-125 (76.1%), high NT-proBNP and low CA-125 (64.7%) and high NT-proBNP and high CA-125 levels (54.3%) (p < 0.001). Addition of CA-125 in combination with NT-proBNP and established risk factors further increased the predictive power for mortality in patients with ADHF. CONCLUSION: CA-125 was an independent factor associated with all-cause mortality in patients with ADHF. Combination of CA-125 with NT-proBNP significantly improved the prediction of mortality in patients with ADHF.
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Yoon et al. (2019) conducted an observational in Acute decompensated heart failure (n=413). Elevated CA-125 levels vs. Lower CA-125 levels was evaluated on All-cause mortality (HR 1.23, 95% CI 1.02-1.48, p=0.030). Elevated log CA-125 was independently associated with all-cause mortality (HR 1.23), and combining CA-125 with NT-proBNP significantly improved risk prediction in acute decompensated heart failure.
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