This review explores the pathophysiological mechanisms and associations between basal septal hypertrophy and heart failure with normal ejection fraction.
Basal septal hypertrophy may contribute to HFpEF pathophysiology; leaves open causal role and need for prospective trials.
A significant clinical problem is patients presenting with exercise-limiting dyspnoea, sometimes with associated chest pain, in the absence of detectable left ventricular (LV) systolic dysfunction, coronary artery disease, or lung disease. Often the patients are older, female, and have isolated basal septal hypertrophy (BSH), frequently on a background of mild hypertension. The topic of breathlessness in patients with clinical heart failure, but who have a normal ejection fraction (HFNEF) has attracted significant controversy over the past few years. This review aims to analyse the literature on BSH, identify the possible associations between BSH and HFNEF, and consequently explore possible pathophysiological mechanisms whereby clinical symptoms are experienced.
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Kelshiker et al. (2014) studied this question.
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