June 1, 2000Journal of Biological ChemistryOpen Access

Identification of the Functional Domain in the Transcription Factor RTEF-1 That Mediates α1-Adrenergic Signaling in Hypertrophied Cardiac Myocytes

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Population

Hypertrophied cardiac myocytes

Comparison

Site-directed mutagenesis of RTEF-1 and chimeric… vs Wild-type RTEF-1 and TEF-1

Design

Preclinical

Authors

TUTakahisa UeyamaKurume University CZChongxue ZhuWenzhou Medical University YVYunuen M. ValenzuelaUniversidad Nacional Autónoma de México

Discussion

Member takes

Implication

Ser-322 may modulate alpha1-adrenergic hypertrophy signaling; hypothesis-generating in animal models and should not yet change practice.

Structured PICO

Population

Hypertrophied cardiac myocytes

Intervention

Site-directed mutagenesis of RTEF-1 (mutation of Ser-322) and chimeric TEF-1/RTEF-1 expression constructs

Comparator

Wild-type RTEF-1 and TEF-1

Outcome

alpha1-adrenergic activation of RTEF-1 and skeletal muscle alpha-actin promotersurrogate

The study identifies Ser-322 in the carboxyl-terminal domain of RTEF-1 as the key residue mediating alpha1-adrenergic signaling in hypertrophied cardiac myocytes.

Cite This Study

Ueyama et al. (2000) studied this question.

synapsesocial.com/papers/6a8534014edd3eca19cf238f https://doi.org/10.1074/jbc.m001970200

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Identification of the Functional Domain in the Transcription Factor RTEF-1 That Mediates α1-Adrenergic Signaling in Hypertrophied Cardiac Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of the Functional Domain in the Transcription Factor RTEF-1 That Mediates α1-Adrenergic Signaling in Hypertrophied Cardiac Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider