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December 1, 1964American Journal of Physiology-Legacy Content

Preparation of vesicular relaxing factor from bovine heart tissue

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Population

Bovine heart tissue

Design

Preclinical

Authors

GIGiuseppe InesiElectrophysiologySESetsuro EbashiThe University of TokyoSWShizuo WATANABETokyo Metropolitan Government

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Overview

Extends sarcoplasmic reticulum calcium-binding role to cardiac muscle; leaves open translation to human physiology.

Structured PICO

P
Population
Bovine heart tissue
I
Intervention
Preparation of a particulated fraction (microsomal suspension) with addition of α-tocopherol
O
Outcome
Calcium-binding capacity and inhibition of myosin B superprecipitationsurrogate

Provides early evidence that the sarcoplasmic reticulum in cardiac muscle plays essentially the same role in calcium binding as in skeletal muscle.

Cite This Study

Inesi et al. (1964) studied this question.

synapsesocial.com/papers/6a853a8df9033a4f45d97bb5https://doi.org/10.1152/ajplegacy.1964.207.6.1339
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relaxation of mammalian single cardiac cells after pretreatment with the detergent Brij‐58.1978 · 49 citations
  2. 2Cardiac Sarcotubular Vesicles1967 · 29 citations
  3. 3Structural and Functional Characterization of Dog Heart Microsomes1969 · 49 citations
  4. 4The nature of the modulation of Ca2+ transport as studied by reconstitution of cardiac sarcoplasmic reticulum.1986 · 126 citations
  5. 5Isolation and characterization of canine cardiac sarcoplasmic reticulum with improved Ca2+ transport properties.1983 · 164 citations