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April 1, 1964Journal of General Microbiology

The Fixation of Complement by Virus-Antibody Complexes: Equivalence and Inhibition in the Reactions of the Viruses of Tomato Bushy Stunt and Foot-and-Mouth Disease with Rabbit and Guinea-Pig Antisera

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Population

In vitro system using components of foot-and-mouth disease virus, tomato bushy stunt virus, bovine plasma…

Design

Preclinical

Authors

CBC. J. BradishThe Pirbright InstituteRJR. E. JowettThe Pirbright InstituteJKJ. KirkhamThe University of Melbourne

Discussion

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Overview

Challenges equivalence assumptions in complement-fixation assays; leaves open refined quantitative models for viral serology research.

Structured PICO

P
Population
In vitro system using components of foot-and-mouth disease virus, tomato bushy stunt virus, bovine plasma albumin, and rabbit or guinea-pig hyperimmune sera
I
Intervention
Complement-fixation test (viral antigen and antibody reacting for up to 90 min at 37° before adding complement)
O
Outcome
Complement fixation (quantitative data defining regions of antibody excess, equivalence, and antigen excess)surrogate

The study describes a sensitive complement-fixation test demonstrating that complement binding is a secondary process to antigen-antibody complex formation and that maintaining equivalence via a constant antigen/antibody ratio is not a valid principle for interpreting such data.

Cite This Study

Bradish et al. (1964) studied this question.

synapsesocial.com/papers/6a853c8464694fc428d97c49https://doi.org/10.1099/00221287-35-1-27
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Complement-Fixation Test in Studies of Components of the Virus System of Foot-and-Mouth Disease and its Antibodies1960 · 20 citations
  2. 2Ultracentrifugal studies of the infective and complement-fixing components in the virus system of foot-and-mouth disease1952 · 31 citations
  3. 3On the Mechanism of Complement Fixation1912 · 14 citations
  4. 4Quantitative Studies of Complement Fixation.1947 · 11 citations
  5. 5The Relation of Antigen to Antibody (Precipitin) in Vitro1923 · 16 citations