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The complement fixation test using heated antigens (CFt character) may serve as a simple in vitro marker to differentiate virulent from attenuated poliovirus strains.
Since the initial description of the complement fixation reaction in 19O1, the complement fixation test by viruses has been widely studied. Despite the immense literature accumlated on the diagnosis of viral disease with the complement fixation test, little information is available on the differentiation of strains with the complement fixation test.The present auther has recently discovered an in vitro marker which may be used to differentiate poliovirus particles with the complement fixation test.
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MASAHISA SHINGU (1961) studied this question.
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