Why the study?
Does methadone dose correlate with increased QTcF interval prolongation in patients on methadone maintenance treatment?
Population
Patients on methadone maintenance treatment (MMT) from pooled data of five clinical trials
Design
Other
Authors
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High-dose methadone was associated with clinically relevant QTcF prolongation; leaves open whether routine ECG monitoring is warranted.
Does methadone dose correlate with increased QTcF interval prolongation in patients on methadone maintenance treatment?
Methadone doses >120 mg/day are associated with clinically significant QT prolongation, supporting the need for ECG monitoring in these patients.
Florian et al. (2012) studied this question.
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