July 1, 1989AJP Heart and Circulatory Physiology

Effects of PAF and BN 52021 on cardiac function and regional blood flow in conscious rats

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Population

Conscious rats

Design

Preclinical

Authors

ASAnna‐Leena SirénUniversity of Würzburg GFG FeuersteinLa Roche College

Discussion

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Implication

PAF-receptor blockade modulates hemodynamics in animal models; leaves open translation to human endotoxemia or anaphylaxis.

Structured PICO

Population

Conscious rats

Intervention

Intravenous injections of platelet-activating factor (PAF) (0.1-3 nmol/kg) with or without selective PAF-receptor antagonists BN 52021 (15 mg/kg) and SDZ 63-441 (1 mg/kg)

Outcome

Blood pressure, heart rate, cardiac output, and regional blood flow (hindquarter, renal, mesenteric)surrogate

PAF acts as a potent vasodilator at low doses and a cardiac depressant at high doses, with its hemodynamic effects effectively blocked by specific antagonists, suggesting potential therapeutic roles in endotoxemia and anaphylaxis.

Cite This Study

Sirén et al. (1989) studied this question.

synapsesocial.com/papers/6a853dc90b777c8ef0964868 https://doi.org/10.1152/ajpheart.1989.257.1.h25

View Full Paper

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Effects of PAF and BN 52021 on cardiac function and regional blood flow in conscious rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of PAF and BN 52021 on cardiac function and regional blood flow in conscious rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider