Why the study?
Does vardenafil prevent the development of HFpEF in a rat model of type 2 diabetes?
Population
Zucker diabetic fatty (ZDF) rats (model of HFpEF) and ZDF lean rats (controls)
Comparison
Vardenafil 10 mg/kg body weight per os from… vs Vehicle
Design
Preclinical
Follow-up
25 weeks (from week 7 to 32 of age)
Authors
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Hypothesis-generating for PDE5 inhibition in diabetic HFpEF prevention; human trials needed before clinical consideration.
Does vardenafil prevent the development of HFpEF in a rat model of type 2 diabetes?
Long-term preventive application of the PDE5A inhibitor vardenafil prevented the development of diabetes mellitus-associated HFpEF in a rat model.
Mátyás et al. (2016) studied this question.
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