October 1, 1997Journal of Hypertension

Antisense oligodeoxynucleotide complementary to platelet-derived growth factor A-chain messenger RNA inhibits the arterial proliferation in spontaneously hypertensive rats without altering their blood pressures

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Why the study?

Does antisense ODN to PDGF A-chain mRNA reduce arterial proliferation in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats and Wistar-Kyoto rats

Comparison

15-Mer antisense oligodeoxynucleotide… vs Non-sense ODN of identical proportion but with a…

Design

Preclinical

Follow-up

28 days

Authors

NFNoboru FukudaUniversity of Pittsburgh AKAtsushi KuboMeiji University of Integrative Medicine YWYoshiyasu WatanabeNihon University

Discussion

Member takes

Implication

Supports PDGF A-chain inhibition for BP-independent vascular remodeling in rat models; leaves open translation to human hypertension.

Structured PICO

Does antisense ODN to PDGF A-chain mRNA reduce arterial proliferation in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (in vitro vascular smooth muscle cells and in vivo models)

Intervention

15-Mer antisense oligodeoxynucleotide (ODN) complementary to the initiation codon region of rat PDGF-A chain mRNA (infused for 28 days in vivo)

Comparator

Non-sense ODN of identical proportion but with a random order of bases

Outcome

Arterial proliferation (DNA synthesis, DNA content, [3H]-thymidine uptake) and systolic blood pressuresurrogate

Inhibition of PDGF A-chain by antisense ODN suppresses arterial proliferation in spontaneously hypertensive rats without affecting blood pressure, suggesting that arterial proliferation in hypertension is partly independent of high blood pressure.

Cite This Study

Fukuda et al. (1997) studied this question.

synapsesocial.com/papers/6a853ea1f14ace264a43d57c https://doi.org/10.1097/00004872-199715100-00010

Topics

Hypertension management

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Antisense oligodeoxynucleotide complementary to platelet-derived growth factor A-chain messenger RNA inhibits the arterial proliferation in spontaneously hypertensive rats without altering their blood pressures

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Antisense oligodeoxynucleotide complementary to platelet-derived growth factor A-chain messenger RNA inhibits the arterial proliferation in spontaneously hypertensive rats without altering their blood pressures

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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