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September 1, 1998AJP Regulatory Integrative and Comparative Physiology

Mechanisms of spontaneous baroreflex impairment in Lyon hypertensive rats

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Population

Lyon genetically hypertensive (LH), normotensive (LN), and low blood pressure (LL) rats

Comparison

Early chronic converting enzyme inhibition with… vs Control animals and normotensive/low blood…

Design

Preclinical

Follow-up

4 weeks (for ANG II infusion)

Authors

PLPierre LantelmeUniversité Claude Bernard Lyon 1CCCatherine CeruttiUniversité Claude Bernard Lyon 1MLMing LoUniversité Claude Bernard Lyon 1

Discussion

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Implication

Angiotensin II may impair baroreflex sensitivity independently of blood pressure in this model; leaves open translation to human hypertension.

Structured PICO

P
Population
Lyon genetically hypertensive (LH), normotensive (LN), and low blood pressure (LL) rats
I
Intervention
Early chronic converting enzyme inhibition with perindopril, followed by 4-week infusion of ANG II, and acute ANG II blockade with losartan
C
Comparator
Control animals (untreated) and normotensive/low blood pressure strains
O
Outcome
Spontaneous baroreflex sensitivity (SBRS)surrogate

In Lyon hypertensive rats, impaired spontaneous baroreflex sensitivity is mediated by cardiac hypertrophy or direct angiotensin II effects rather than elevated blood pressure alone.

Cite This Study

Lantelme et al. (1998) studied this question.

synapsesocial.com/papers/6a854065e3de713998f246eehttps://doi.org/10.1152/ajpregu.1998.275.3.r920

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship between cardiovascular hypertrophy and cardiac baroreflex function in spontaneously hypertensive and stroke-prone rats1993 · 69 citations
  2. 2Assessment of spontaneous baroreflex sensitivity in rats a new method using the concept of statistical dependence1995 · 32 citations
  3. 3Chronic Infusion of Angiotensin II Resets Baroreflex Control of Heart Rate by an Arterial Pressure–Independent Mechanism1995 · 44 citations
  4. 4Reversibility of baroreceptor hyposensitivity during reversal of hypertension.1990 · 23 citations
  5. 5Baroreceptor-heart rate reflex function before and after surgical reversal of two-kidney, one-clip hypertension in the rat.1990 · 19 citations