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Protamine sulphate exhibits concentration-dependent anticoagulant effects by interfering with thromboplastin generation and its interaction with prothrombin and calcium.
Protamine sulphate in low concentrations affects both rate and yield of blood thromboplastin but has no effect on formed thromboplastin. Relatively higher concentrations inhibit a reaction between blood thromboplastin, prothrombin and calcium.
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Cecil Hougie (1958) studied this question.
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