Why the study?
Does protamine sulphate reduce bleeding induced by the pentasaccharide SR 80027 without affecting its antithrombotic activity in rats?
Population
Anaesthetized rats
Comparison
Protamine sulphate following administration of… vs Protamine sulphate following standard heparin
Design
Preclinical
Authors
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May allow selective reversal of pentasaccharide bleeding in rats; hypothesis-generating and requires human studies before any clinical consideration.
Does protamine sulphate reduce bleeding induced by the pentasaccharide SR 80027 without affecting its antithrombotic activity in rats?
Protamine sulphate effectively reverses bleeding induced by the pentasaccharide SR 80027 without compromising its antithrombotic efficacy in a rat model.
Bernat et al. (2009) studied this question.
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