Why the study?
Does protamine sulfate reduce bleeding induced by the anti-factor Xa pentasaccharide SR 90107A/Org 31540 in rats and mice?
Population
Anaesthetised rats and mice
Comparison
Protamine sulfate administered after bleeding… vs No protamine sulfate (implied)
Design
Preclinical
Authors
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Protamine may attenuate pentasaccharide bleeding in animal models without compromising efficacy; hypothesis-generating for human antidote trials.
Does protamine sulfate reduce bleeding induced by the anti-factor Xa pentasaccharide SR 90107A/Org 31540 in rats and mice?
Protamine sulfate may serve as a potential antidote to neutralize bleeding side-effects from SR 90107A/Org 31540 overdosing without compromising its antithrombotic efficacy.
Bernat et al. (1996) studied this question.
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