Why the study?
Does protamine sulfate reduce enoxaparin-induced bleeding in a rabbit model?
Population
Rabbit model
Comparison
Protamine sulfate administered after enoxaparin… vs Enoxaparin or unfractionated heparin without…
Design
Preclinical
Authors
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May support protamine for enoxaparin reversal in vivo; leaves open clinical translation from this animal model.
Does protamine sulfate reduce enoxaparin-induced bleeding in a rabbit model?
Protamine sulfate is an effective in vivo antidote for enoxaparin-induced bleeding despite its inability to completely neutralize anti-factor Xa activity ex vivo.
Ryn-McKenna et al. (1990) studied this question.
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