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March 9, 2006The Journal of PhysiologyOpen Access

Central respiratory modulation of barosensitive neurones in rat caudal ventrolateral medulla

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Population

Chloralose-anaesthetized, ventilated, neuromuscularly blocked, vagotomized rats

Design

Preclinical

Authors

DMDaniel MandelASAnn M. Schreihofer

Discussion

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Overview

Supports preclinical models of CVLM cardiorespiratory coupling; leaves open translation to human sympathetic regulation.

Structured PICO

P
Population
Chloralose-anaesthetized, ventilated, neuromuscularly blocked, vagotomized rats
I
Intervention
Examination of firing patterns of individual barosensitive caudal ventrolateral medulla (CVLM) neurones in relation to phrenic nerve activity
O
Outcome
Patterns of central respiratory drive (CRD)-related activity in baro-activated CVLM neuronessurrogate

Baro-activated GABAergic neurones in the CVLM display central respiratory drive-related activity, suggesting they contribute to the respiratory modulation of sympathetic nerve activity.

Cite This Study

Mandel et al. (2006) studied this question.

synapsesocial.com/papers/6a85448fc12175303ef23ce1https://doi.org/10.1113/jphysiol.2005.103622
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Baro-Activated Neurons With Pulse-Modulated Activity in the Rat Caudal Ventrolateral Medulla Express GAD67 mRNA2003 · 87 citations
  2. 2Electrophysiological study of cardiovascular neurons in the rostral ventrolateral medulla in rats.1985 · 349 citations
  3. 3GOOD VIBRATIONS? RESPIRATORY RHYTHMS IN THE CENTRAL CONTROL OF BLOOD PRESSURE1995 · 46 citations
  4. 4The human respiratory gate2003 · 409 citations
  5. 5Entrainment pattern between sympathetic and phrenic nerve activities in the Sprague-Dawley rat: hypoxia-evoked sympathetic activity during expiration2004 · 70 citations