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August 1, 1989AJP Regulatory Integrative and Comparative Physiology

Neurons in rostral VLM are inhibited by chemical stimulation of caudal VLM in rats

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Population

Urethan-anesthetized male Wistar rats; 88 neurons in the rostral ventrolateral medulla recorded.

Design

Preclinical

Authors

SAS. K. AgarwalIndian Agricultural Statistics Research InstituteAGA. J. GelsemaWestern UniversityFCF. R. CalaresuWestern University

Discussion

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Implication

Supports inhibitory CVLM-RVLM signaling in rodents; leaves open any role in human cardiovascular disease.

Structured PICO

P
Population
Urethan-anesthetized male Wistar rats (spontaneously breathing and artificially ventilated); 88 neurons in the rostral ventrolateral medulla (RVLM) recorded.
I
Intervention
Microinjection of 2-30 nl sodium glutamate (0.15 M) into depressor sites of the caudal ventrolateral medulla (CVLM).
O
Outcome
Firing rate/discharge of neurons in the rostral ventrolateral medulla (RVLM).surrogate

This study provides direct evidence for an inhibitory neural pathway from the caudal to the rostral ventrolateral medulla regulating cardiovascular function.

Cite This Study

Agarwal et al. (1989) studied this question.

synapsesocial.com/papers/6a987265e58ec8b8f024becbhttps://doi.org/10.1152/ajpregu.1989.257.2.r265
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Also Consider

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  1. 1Inhibition of rostral VLM by baroreceptor activation is relayed through caudal VLM1990 · 81 citations
  2. 2Supramedullary inputs to cardiovascular neurons of rostral ventrolateral medulla in rats1993 · 42 citations
  3. 3Somatic and visceral inputs to neurons of the rostral ventrolateral medulla1993 · 29 citations
  4. 4Role of ventrolateral medulla in reflex cardiovascular responses to activation of skin and muscle nerves1995 · 11 citations
  5. 5Differentiation of two cardiovascular regions within caudal ventrolateral medulla1991 · 111 citations