Supramedullary inputs to cardiovascular neurons of rostral ventrolateral medulla in rats

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Population

Urethan-anesthetized rats; 32 units classified as cardiovascular neurons in the rostral ventrolateral medulla

Design

Preclinical

Authors

Discussion

Supports brainstem pathway mapping in rats; leaves open translation to human cardiovascular regulation.

Population

Urethan-anesthetized rats; 32 units classified as cardiovascular neurons in the rostral ventrolateral medulla (RVLM)

Intervention

Chemical stimulation with sodium glutamate of the lateral parabrachial nucleus (LPBN), locus ceruleus (LC), and lateral hypothalamic area (LHA)

Outcome

Changes in firing frequency of RVLM neuronssurrogate

The study provides direct evidence for excitatory and inhibitory pathways from the LPBN, LC, and LHA to cardiovascular neurons in the RVLM in rats.

Agarwal et al. (1993) studied this question.

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