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March 1, 2003Journal of Neurophysiology

Baro-Activated Neurons With Pulse-Modulated Activity in the Rat Caudal Ventrolateral Medulla Express GAD67 mRNA

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Key result

All 12 examined baro-activated, pulse-modulated CVLM neurons in rats expressed GAD67 mRNA, demonstrating they are GABAergic interneurons that mediate the sympathetic baroreceptor reflex.

Population

Chloralose-anesthetized rats

Comparison

Extracellular recording, biotinamide filling… vs Adjacent baro-inhibited CVLM cells

Design

Preclinical

Authors

ASAnn M. SchreihoferUniversity of North TexasPGPatrice G. GuyenetUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Reinforces CVLM interneuron mapping in rat baroreflex models; hypothesis-generating for autonomic circuits with no immediate clinical implications.

Structured PICO

P
Population
19 baro-activated, pulse-modulated CVLM neurons recorded in chloralose-anesthetized rats.
E
Exposure
Extracellular recording, biotinamide filling, and examination for GAD67 mRNA and choline acetyltransferase (ChAT) immunoreactivity
C
Comparator
Adjacent baro-inhibited CVLM cells
O
Outcome
Expression of GAD67 mRNA and ChAT immunoreactivity in baro-activated CVLM neuronssurrogate

Baro-activated, pulse-modulated neurons in the rat CVLM are GABAergic, supporting their role as interneurons that mediate the sympathetic baroreceptor reflex.

Cite This Study

Schreihofer et al. (2003) studied this question. Baro-activation (increased arterial pressure) vs. Baro-inhibited CVLM cells was evaluated on Expression of GAD67 mRNA. All 12 examined baro-activated, pulse-modulated CVLM neurons in rats expressed GAD67 mRNA, demonstrating they are GABAergic interneurons that mediate the sympathetic baroreceptor reflex.

synapsesocial.com/papers/6a46fe46f81ec6c7245ed05dhttps://doi.org/10.1152/jn.00737.2002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neurons in rostral VLM are inhibited by chemical stimulation of caudal VLM in rats1989 · 66 citations
  2. 2Identification of baroreceptor reflex interneurons in the caudal ventrolateral medulla1993 · 111 citations
  3. 3Electrophysiological study of cardiovascular neurons in the rostral ventrolateral medulla in rats.1985 · 349 citations
  4. 4Medullary pathway of the Bezold-Jarisch reflex in the rat1992 · 123 citations
  5. 5Responses of aortic depressor nerve‐evoked neurones in rat nucleus of the solitary tract to changes in blood pressure2000 · 36 citations