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January 1, 1998The Japanese Journal of PharmacologyOpen Access

Pulmonary Edema Induced by Angiotensin I in Rats

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Population

Rats with pulmonary edema induced by angiotensin I (20 μg/kg) or adrenaline (25 μg/kg)

Design

Preclinical

Authors

ZXZhe-Hu XuKSKazuro ShimakuraTokyo Medical and Dental UniversityTYTakatsugu YamamotoTeikyo University

Discussion

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Implication

Reinforces angiotensin II mediation of experimental pulmonary edema; leaves open clinical translation and should not change practice.

Structured PICO

P
Population
Rats with pulmonary edema induced by angiotensin I (20 μg/kg) or adrenaline (25 μg/kg)
I
Intervention
Captopril (5, 10, 20 mg/kg), losartan (10 mg/kg), or phentolamine (10 mg/kg)
O
Outcome
Development of pulmonary edemasurrogate

Angiotensin I-induced pulmonary edema in rats is mediated via angiotensin II and its specific receptor, independent of adrenaline.

Cite This Study

Xu et al. (1998) studied this question.

synapsesocial.com/papers/6a854c7ea95ccb34714e179bhttps://doi.org/10.1254/jjp.76.51
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pulmonary Edema Induced by Angiotensin II in Rats1995 · 10 citations
  2. 2Effects of losartan and captopril on endothelin-1 production in blood vessels and glomeruli of rats with reduced renal mass1998 · 65 citations
  3. 3Angiotensin II Receptor Blockade After Myocardial Infarction in Rats1992 · 175 citations
  4. 4Angiotensin II-Induced Pulmonary Edema in a Rabbit Model.1997 · 38 citations
  5. 5Mechanism of Captopril-Induced Renin Release in Conscious Rats1981 · 30 citations