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April 1, 1997The Journal of Pathology

Increased Expression of Il-15 in the Synovium of Patients With Rheumatoid Arthritis Compared With Patients Withyersinia-Induced Arthritis and Osteoarthritis

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Population

29 patients total: 10 with rheumatoid arthritis, 10 with Yersinia enterocolitica-induced reactive arthritis…

Design

Cross-sectional

Authors

ETErik W. ThurkowIHIneke M. van der HeijdenFBFerdinand C. Breedveld

Discussion

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Overview

IL-15 elevation in RA synovium supports targeted research; hypothesis-generating and should not yet change practice.

Structured PICO

P
Population
29 patients total: 10 with rheumatoid arthritis (RA), 10 with Yersinia enterocolitica-induced reactive arthritis (ReA), and 9 with osteoarthritis (OA).
C
Comparator
Synovial tissue from patients with ReA and OA
O
Outcome
Expression of IL-15 in synovial tissuesurrogate

IL-15 expression is specifically increased in the rheumatoid synovium, suggesting a role in the accumulation and activation of inflammatory cells in RA.

Cite This Study

Thurkow et al. (1997) studied this question.

synapsesocial.com/papers/6a85548e73102ab9cdb550c0https://doi.org/10.1002/(sici)1096-9896(199704)181:4<444::aid-path778>3.0.co;2-o
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential expression of pro-inflammatory cytokines IL-15Ralpha, IL-15, IL-6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients2015 · 54 citations
  2. 2Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis1999 · 246 citations
  3. 3Quantitative analysis of cytokine gene expression in rheumatoid arthritis.1990 · 603 citations
  4. 4Interleukin-16, produced by synovial fibroblasts, mediates chemoattraction for CD4+ T lymphocytes in rheumatoid arthritis1998 · 116 citations
  5. 5Interleukin-10, Interleukin- 16 and Interferon-γ in serum of patients with rheumatoid arthritis and correlation with disease activity2005 · 1 citations