Metabolic Profiling of Adiponectin Levels in Adults

Figures

• 

  Figure 1.. Schematic representation of studies contributing to each analytic approach. From the available data sources, 3 had data on adiponectin and metabolic measures and could contribute to multivariable analysis (PEL82 [1982 Pelotas Birth Cohort], BWHHS [British Women’s Heart and Health Study], and WHII study [Whitehall II]), and all had data on genetic variants and metabolic measures and could contribute to Mendelian randomization analysis (PEL82, BWHHS, WHII, CaPS [the Caerphilly Prospective Study], UKCTOCS [the United Kingdom Collaborative Trial of Ovarian Cancer Screening], ALSPAC-M [Cohort of Mothers From the Avon Longitudinal Study of Children and Parents], and Metabolomics consortium).

• 

  Figure 2.. Association of lipoprotein traits with blood adiponectin levels from multivariable and Mendelian randomization (MR) analysis. Values are expressed as units of standardized metabolite concentration (and 95% CI [confidence interval]) per 1 U increment of standardized log adiponectin levels. P values for the association between adiponectin and metabolites are indicated by *** if lower than Bonferroni-adjusted threshold (P value <0.0019). Heterogeneity was considered substantial if I2=50% to 75% (+) or high if I2>75% (++). P values for the comparison between multivariable and MR estimates are displayed in the column MR vs MV (P value). Metabolic measures were adjusted for age, sex, and, if applicable, place of recruitment (BWHHS [British Women’s Heart and Health Study] and UKCTOCS [the United Kingdom Collaborative Trial of Ovarian Cancer Screening]) or principal components of genomic ancestry (PEL82 [1982 Pelotas Birth Cohort] and some studies contributing to Metabolomics consortium), and the resulting residuals were transformed to normal distribution by inverse rank-based normal transformation. A indicates the Avon Longitudinal Study of Children and Parents-Mothers’ Cohort; Apo,…

• 

  Figure 3.. Association of multiple metabolic measures with blood adiponectin levels from multivariable and Mendelian randomization (MR) analysis. Values are expressed as units of standardized metabolite concentration (and 95% CI [confidence interval]) per 1 U increment of standardized log adiponectin levels. P values for the association between adiponectin and metabolites are indicated by *** if lower than Bonferroni-adjusted threshold (P value <0.0019). Heterogeneity was considered substantial if I2=50% to 75% (+) or high if I2>75% (++). P values for the comparison between multivariable and MR estimates are displayed in the column MR vs MV (P value). Metabolic measures were adjusted for age, sex, and, if applicable, place of recruitment (BWHHS [British Women’s Heart and Health Study] and UKCTOCS [the United Kingdom Collaborative Trial of Ovarian Cancer Screening]) or principal components of genomic ancestry (PEL82 [1982 Pelotas Birth Cohort] and some studies contributing to Metabolomics consortium) and the resulting residuals were transformed to normal distribution by inverse rank-based normal transformation. A indicates the Avon Longitudinal Study of Children and Parents-Mothers’ Cohort;…

• 

  Figure 4.. Correlation between estimates from multivariable regression and Mendelian randomization (MR). Apo indicates apolipoprotein; CLA, conjugated linoleic acids, CRP, C-reactive protein; DAG, diglycerides; DBP, diastolic blood pressure; DHA, docosahexaenoic acid; FAw3, omega-3 fatty acid; FAw6, omega-6 fatty acid; GlycA, glycoprotein acetyls; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; HDL-C, HDL cholesterol; HDLd, HDL particle mean diameter; IDL, intermediate-density lipoprotein; IDL-C, IDL cholesterol; IL-6, interleukin-6; L-HDL, large HDL; L-LDL, large LDL; L-VLDL, large VLDL; LA, linoleic acid; LDL, low-density lipoprotein; LDL-C, LDL cholesterol; LDLd, LDL particle mean diameter M-HDL, medium HDL; M-LDL, medium LDL; M-VLDL, medium VLDL; MUFA, monounsaturated fatty acid; r, Pearson correlation coefficient; S-HDL, small HDL; S-LDL, small LDL; S-VLDL, small VLDL; SBP, systolic blood pressure; SFA, saturated fatty acid; TG, triglycerides; VLDL, very-low-density lipoprotein; VLDL-C, VLDL cholesterol; VLDLd, VLDL particle mean diameter; XL-HDL, very large HDL; XL-VLDL, very large VLDL; XS-VLDL, very small VLDL; and XXL-VLDL, extremely large VLDL.