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September 3, 2014American Journal of HypertensionOpen Access

Gene–Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study

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Population

6,889 participants from the Framingham Heart Study

Design

Cohort

Authors

YSYun Ju SungWashington University in St. LouisLFLisa de las FuentesGeneral CardiologyKSKaren SchwanderBoston University

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Overview

Novel BP loci from SNP-smoking interactions extend gene discovery; leaves open clinical translation pending validation.

Structured PICO

P
Population
6,889 participants from the Framingham Heart Study
O
Outcome
Blood pressure (BP) loci identified via SNP-smoking interaction effectssurrogate

Genome-wide analysis of SNP-smoking interactions identified several novel and biologically plausible blood pressure loci, enhancing gene discovery for BP regulation.

Cite This Study

Sung et al. (2014) studied this question.

synapsesocial.com/papers/6a855a4247743a7c6cd4cb79https://doi.org/10.1093/ajh/hpu149
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